[Bike...and Dennis]

Is it actually running rough and trying to die, or seems to be OK except for the lack of difference? We've seen several on this forum that removing a plug wire doesn't seem to change much, yet the machine idles and runs out pretty well, considering age and abuse.
Mine doesn't change much when the #1 plug is pulled. A worn cam, I suspect, as new carbs didn't change the symptom and compression is A+.

 

[Bike...and Dennis]

I do have a good spark at idle, good compression, if I pull #1 or #2 it will die . I am getting a good blue spark on all of them. could it be the carbs need adjustment?

Yes, it may mean a carb has an issue, but my bet is no. If you don't have any other symptoms and it idles smoothly, why mess that up?