Missouri Ride Planning

It's that time of year for us midwesterners to start talking about trips planned this year. Our spring trips generally head south, in past years we have gone to Nashville, and Memphis a couple times. This year we plan to head to Missouri. Just a 3 day trip likely. We leave from the general area of Peoria IL and will head towards Hannibal MO, then on to "the Ozarks", then try to hit alot of the Mark Twain National Forest on our way east toward the "wine area" I am told is west of St. Louis. Anyone have experience in those areas that would care to share good places to eat, sleep, stop and see, etc.? I'd love to hit some wineries and bring back a case.