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Welcome to the site Kluke!
The 1200's are great bikes and would serve you well. The 1500 has a bit more power so if you could come up with a little more $$, that would be a better move IMHO. Your wife will have more room on the 1500 than the 1200 too. Either bike is great though, they're Wings.
I wouldn't say theirs too much specific about any of the years on the 1200's to watch out for, except the early models had so ignition switch problems, so make sure that's working well. For any of them, if they are near 60,000 miles or over, find out if the stator/alternator has been replaced. The original stators averaged around 60K before they go out, and require pulling the engine to replace. There's a poorboy alternative though. You can search on poorboy on this site and find lots of info on that.
On the 1500, they made an Interstate for I think 6 or 7 years. They don't have reverse or cruise control. Reverse is the biggie to me but may not be to you. The Interstates tend to sell for a bit less than the Aspencades and SE's due to them having less options.
Check out the buyers guide on this site for some great info,
http://www.goldwingfacts.com/usedgoldwing.htm.
Also check out the GoldWing history page for info on all the changes over the years.
http://www.goldwingfacts.com/goldwinghistory.htm
As for life span, hard to say for sure, but a long time and lots of miles. I've personally seen 200,000 + mile 1200's still going strong, and I saw a 500,000 mile 1500 sell on ebay with the original owner claiming it still was strong and used no oil. There are many out there with more than 100,000 miles.
One final note, because of your size, I would definitely plan on installing Progressive springs in the forks and Progressive shocks on the back, if the bike does not already have them. You will probably need the extra spring strength for the best ride and control. Their shocks are expensive, but worth it.
John